Roberto Chiarle Selected Research

Neoplasms (Cancer)

4/2024	Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells.
1/2024	Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers.
12/2023	ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells.
11/2023	Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers.
11/2023	SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment.
10/2023	Effects of blocking CD24 and CD47 'don't eat me' signals in combination with rituximab in mantle-cell lymphoma and chronic lymphocytic leukaemia.
1/2023	ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer.
1/2023	Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma.
10/2022	Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.
12/2021	Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.

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Roberto Chiarle Research Topics

Disease

57	Neoplasms (Cancer) 04/2024 - 04/2002
26	Lymphoma (Lymphomas) 01/2023 - 04/2002
24	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2022 - 02/2002
10	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2023 - 12/2012
8	Genetic Translocation (Chromosomal Translocation) 01/2024 - 06/2005
6	T-Cell Lymphoma (Lymphoma, T Cell) 01/2022 - 03/2003
6	Carcinogenesis 10/2017 - 02/2004
5	Neuroblastoma 12/2023 - 06/2011
4	Lung Neoplasms (Lung Cancer) 01/2022 - 12/2011
4	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2022 - 04/2002
4	Breast Neoplasms (Breast Cancer) 03/2017 - 10/2003
4	Carcinoma (Carcinomatosis) 01/2015 - 11/2009
4	Pancreatic Neoplasms (Pancreatic Cancer) 09/2013 - 08/2009
4	Adenocarcinoma 05/2013 - 10/2007
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2024 - 04/2012
3	Inflammation (Inflammations) 01/2014 - 10/2003
2	Leukemia 04/2024 - 04/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2024 - 09/2011
2	Down Syndrome Critical Region 10/2023 - 06/2007
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 10/2023 - 01/2017
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2022 - 04/2015
2	B-Cell Lymphoma (Lymphoma, B Cell) 12/2021 - 06/2005
2	Adenocarcinoma of Lung 01/2020 - 10/2017
2	Neoplasm Metastasis (Metastasis) 04/2015 - 02/2010
1	Hematologic Neoplasms (Hematological Malignancy) 12/2023
1	Chemotherapy-Related Cognitive Impairment 10/2022
1	Anemia 01/2022
1	COVID-19 01/2021
1	Neoplastic Cell Transformation 01/2021
1	Fibrosarcoma 10/2020
1	Bites and Stings (Sting) 12/2018

Drug/Important Bio-Agent (IBA)

35	Anaplastic Lymphoma KinaseIBA 12/2023 - 02/2002
18	Proteins (Proteins, Gene)FDA Link 10/2023 - 04/2002
7	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2024 - 02/2002
7	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2004
6	Phosphotransferases (Kinase)IBA 01/2024 - 01/2008
6	AntigensIBA 10/2017 - 10/2007
5	CrizotinibIBA 01/2023 - 12/2012
5	Tyrosine Kinase InhibitorsIBA 01/2023 - 12/2015
5	Tyrosine (L-Tyrosine)FDA Link 01/2022 - 09/2005
5	Small Interfering RNA (siRNA)IBA 10/2020 - 05/2005
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 03/2024 - 10/2017
4	Protein Isoforms (Isoforms)IBA 10/2017 - 11/2009
4	AntibodiesIBA 02/2016 - 05/2007
3	Chimeric Antigen ReceptorsIBA 04/2024 - 02/2016
3	VaccinesIBA 04/2024 - 05/2013
3	RNA (Ribonucleic Acid)IBA 01/2022 - 03/2017
3	Pyridinolcarbamate (P23)IBA 01/2022 - 05/2007
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 11/2009
3	MicroRNAs (MicroRNA)IBA 10/2020 - 04/2015
3	NucleophosminIBA 10/2020 - 12/2006
3	AutoantibodiesIBA 11/2017 - 10/2007
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2011 - 04/2008
2	Neoplasm Antigens (Tumor Antigens)IBA 12/2023 - 06/2008
2	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 11/2023 - 05/2007
2	citron-kinaseIBA 10/2023 - 06/2007
2	Peptides (Polypeptides)IBA 01/2023 - 11/2017
2	Immune Checkpoint InhibitorsIBA 01/2023 - 01/2020
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 02/2004
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022 - 01/2022
2	ras ProteinsIBA 01/2022 - 01/2019
2	Ligases (Synthetase)IBA 12/2021 - 03/2007
2	UbiquitinIBA 12/2021 - 03/2007
2	Formaldehyde (Formol)FDA Link 01/2020 - 03/2017
2	ParaffinIBA 01/2020 - 03/2017
2	GTP Phosphohydrolases (GTPases)IBA 01/2019 - 03/2016
2	EnzymesIBA 11/2017 - 05/2013
2	Estrogen Receptor alphaIBA 03/2017 - 10/2003
2	Biomarkers (Surrogate Marker)IBA 03/2017 - 01/2014
2	Estrogen ReceptorsIBA 03/2017 - 10/2003
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 03/2016 - 04/2008
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2014 - 02/2010
2	Complement System Proteins (Complement)IBA 05/2013 - 04/2013
2	Immunoglobulin G (IgG)IBA 05/2013 - 10/2007
2	Phosphopyruvate Hydratase (Enolase)IBA 05/2013 - 08/2009
2	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2012 - 04/2009
2	Messenger RNA (mRNA)IBA 04/2008 - 03/2007
1	trametinibIBA 03/2024
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 11/2023
1	Rituximab (Mabthera)FDA Link 10/2023
1	AntioxidantsIBA 10/2022
1	GATA1 Transcription FactorIBA 01/2022
1	5' Untranslated Regions (5' UTR)IBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2021
1	ChemokinesIBA 01/2021
1	Interleukin-17 (Interleukin 17)IBA 01/2021
1	CytokinesIBA 01/2021
1	lenzilumabIBA 01/2021
1	VemurafenibIBA 10/2020
1	Interleukin-10 ReceptorsIBA 10/2020
1	Therapeutic UsesIBA 01/2019
1	Wiskott-Aldrich Syndrome ProteinIBA 01/2019
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	Guanosine Triphosphate (GTP)IBA 01/2019
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2019
1	InterferonsIBA 12/2018
1	EpitopesIBA 11/2017

Therapy/Procedure

20	Therapeutics 01/2024 - 10/2007
5	Drug Therapy (Chemotherapy) 10/2023 - 06/2008
2	Immunotherapy 01/2020 - 02/2016